Saturday, March 22, 2014

Can Diabetes Be Cured?
Can Diabetes Be Cured?
Recently, the question was asked: “Can diabetes be totally cured? Will there be any medicine that can cure diabetes totally? ”

My reply:

You may have asked the identical questions which everybody else thinks about, and this everyone hopes could have an answer soon. Unfortunately, the thought of “cure” doesn’t manage to pertain to diabetes.

That’s because diabetes isn’t one particular disease, but a collection of different disorders, a few of which are autoimmune, almost all of which can be genetic, and every one of which involve either the destruction in the pancreas’ capacity to make insulin, or perhaps the body’s capacity to use insulin appropriately (or both). Samples of the several types of diabetes that could need different strategies to be cured: type 1 (autoimmune) diabetes, type 2 (insulin-resistant) diabetes, MODY diabetes (which is truly a name covering at the very least a dozen different monogenetic kinds of diabetes), post-surgical diabetes (after pancreatectomy surgery), bronze diabetes (medically called hemochromatosis), chemically-induced diabetes (including the diabetes induced by Agent Orange) and Cystic Fibrosis-Related Diabetes. Therefore, any cure that eventually could be developed could possibly only affect a percentage of people who may have one of many various forms of diabetes, and wouldn’t be prone to cure the other sorts of diabetes.

Since diabetes has different causes, it’s also not surprising that there’s no single medication that may control, let alone cure, all the various kinds of diabetes. Giving insulin by injection is probably the closest to a magic bullet to treat the hyperglycemia of all the forms of diabetes, but some of the forms can be readily treated without the hassle of injections and the risk of hypoglycemia and weight gain that come with insulin therapy.

The closest to the idea of a medication to cure diabetes, from my way of thinking, isn’t a medication per se, but would be pancreas transplantation - or better still, transplantation of the islet cells of the pancreas. Such transplants have been tried for many years in patients with type 1 diabetes, and occasionally results in the patients remaining off insulin supplementation for long periods of time, but at the price of the patient instead needing to take toxic anti-rejection drugs to decrease the odds that the body will reject the transplant. By the way, there is a rare form of diabetes that can be prevented by transplantation: in patients who definitely are undergoing surgery to eliminate the pancreas to get a condition called chronic pancreatitis, it’s possible to autotransplant their islets through the pancreas that’s being removed and implant them to the patient, thus preventing diabetes from developing.

No comments:

Post a Comment